jokes-on-men

Q uestions answered by wise crack women.
My dear Ladies and Gentlemen, Ladies,

I cannot believe that you are thinking so naughty about men.

Here comes the first Question
and its
answer.
Click on 'Read more' below
if you want to giggle at gigolo.


Q: How do you keep your husband from reading your e-mail?

A: Rename the mail folder to "instruction manuals".



Q. What should you do if you see your ex-husband rolling around in pain on the ground?
A. Shoot him again.


Q. How can you tell when a man is well-hung?
A. When you can just barely slip your finger in between his neck and the nooose.


Q. What do you call the useless piece of skin on the end of a man's penis?
A. His body.


Q. Why do little boys whine?
A. Because they're practicing to be men.


Q. How many men does it take to screw in a light bulb?
A. One - he just holds it up there and waits for the world to revolve around him. OR
A. Three - one to screw in the bulb, and two to listen to him brag about the screwing part.

Q. What do you call a handcuffed man?
A. Trustworthy.


Q. What does it mean when a man is in your bed gasping for breath and calling your name?
A. You didn't hold the pillow down long enough.


Q. Why do doctors slap babies butts right after they're born?
A. To knock the penises off the smart ones.


Q. Why do men name their penises?
A. Because they don't like the idea of having a stranger make 90% of their decisions.


Q. Why does it take 100,000,000 sperm to fertilize one egg?
A. Because not one will stop and ask directions.


Q. Why do female black widow spiders kill their males after mating?
A. To stop the snoring before it starts.


Q: What's the best way to kill a man?
A: Put a naked woman and a six-pack in front of him. Then tell him to pick only one.


Q: What do men and pantyhose have in common?
A: They either cling, run, or don't fit right in the crotch!


Q: Why do men whistle when they're sitting on the toilet?
A: Because it helps them remember which end they need to wipe.


Q: What is the difference between men and women...
A: A woman wants one man to satisfy her every need. A man wants every woman to satisfy his one need.


Q: How does a man keep his youth?
A: By giving her money, furs, and diamonds.

ASK THE DOCTOR

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ASK THE DOCTOR

adultery

Can having an affair disqualify her as teacher, even if she be a married woman?

"How many persons in your government have lost their job on this ground? Such a decision of the state government may prove fatal for women in the future. Do not set such precedents."

The aggrieved woman took this matter to the court, which was presided by Honorable Justices Ranjana Desai and Roshan Dalvi. Having an affair ought not to be reason from dismissal from job. The Judges strongly felt that such a move could become a grave and undesirable precedent.


At Mahabeleshwar, a hill station, close to Mumbai, a teacher was terminated from her job by the zilla parishad in 2005. She was dismissed on the grounds that she had an extramarital affair and should not be around children. A division bench of Justice Ranjana Desai and Roshan Dalvi was told by the petitioner that she was appointed as anganwadi assistant in 2001; she also received an 'Ideal Anganwadi Assistant Certificate' in 2002.
Satara Deputy Chief Executive Officer has also filed an affidavit in the high court supporting the zilla parishad decision of dismissal.Top of this post

The lady's lawyer alleged that the zilla parishad forced her and her husband to admit to the alleged illicit affair and obtained her signature confessing to the same.


***Justice Ranjana Desai of the Bombay High Court to the state government
Reference:
Hindustan Times, Mumbai, December 18, 2007, page 7, Urvi Mahjani Top of this post

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Nude-or-pornography

When does naked, the nude become pornography?
The story of Eduard Manet and the reaction of society is fascinating. Who is to decide nude art and pornography? (I guess dictionary!)

To see enlarged picture of Eduard Manet


go to ©www.allposters.com/gallery
Read ahead



His story featured in spotlight in answers.com on his birth anniversary day.

Édouard Manet, born on this date in 1832, was a painter who greatly influenced impressionists, though he chose not to be identified as one himself. Many of his works scandalized the French, who were especially shocked by his paintings of nudes. In his Luncheon on the Grass a young female sits nude, having lunch with several fully clothed men. When the Salon refused to show the painting, Manet submitted it to the Salon des Refusés, where it was hung and still drew criticism for what viewers considered lewd content.

Quote: "There is only one true thing: instantly paint what you see. When you've got it, you've got it. When you haven't, you begin again. All the rest is humbug." — Édouard Manet

Dr. Ashok Koparday
Source:
picture
copyright ©www.allposters.com/gallery
Text
www.answers.com©

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how-to-detect-pregnancy

HOW TO KNOW THAT THE RESULTS COULD BE FALSE?

To Know if there is Pregnancy Urine Pregnancy Test can be done at home.
Ask for velocity ® in medical shop. This is manufactured and sold in India by Dr. Reddy's Laboratories. It is legally and medically safe and commonly used even by doctors for their patients

FALSE POSITIVE
hCG may remain detectable for a few days
to several days after delivery, abortion, or
natural termination.

A number of conditions other than pregnancy,
trophoblastic disease and certain non-trophoblastic neoplasms including testicular tumors, prostate cancer, breast cancer, and lung cancer, cause elevated levels of hCG. Therefore, the presence of hCG in urine should not be used to diagnose pregnancy unless these conditions have been ruled out.

Drugs which contain hCG result in false positive.
FALSE NEGATIVE
Very low levels of hCG (less than 50 mIU/ml) are present
in urine specimen shortly after implantation.

False negative results may occur when the le
are below the sensitivity level of the test.

As a rule, hCG levels, if you are pregnant, are between 5 - 50 mIU a week before your period is due. The hCG levels in your system should double every two to three days.

In normal pregnancy, hCG can be
detected in serum as early as 7 days following
conception. The concentration of hCG continues
to rise rapidly, frequently exceeding 100 mIU/ml by the
first missed menstrual period and peaking in the
30-200,000 mIU/ml range by 10-12 weeks into
pregnancy.


UPT gives presumptive diagnosis.
Confirmed pregnancy diagnosis should only be made by a physician
References:

http://lib.store.yahoo.net/lib/early-pregnancy-tests/pregnancy.pdf
http://www.hptn.org/Web%20Documents/HPTN035/LaboratoryTraining/UrinePregnancyTest.pdf
http://www.babyhopes.com/pregnancy-test-sensitivity.html

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urine-pregnancy-test-sensitivity

To know whether pregnancy is present Urine Pregnancy Test is done using Urine Pregnancy Test Kit. One brand name that is popular in India is VELOCIT © manufactured and marketed by Dr. Reddy's Laboratories.
In the past

Hence, practically urine pregnancy test can be relied upon not earlier than one week prior to expected date of next period. Commonly UPT is considered sensitive soon after missed period.

to detect pregnancy women used to wait for missed period.

After an embroyo begins to grow, the menses cease. She does not get her period during her expected date.

In case pregnancy is suspected and not wanted as after unprotected sex the couple gets highly strung and immensely worried about the possibility of pregnancy.
Urine Pregnancy Test comes in handy to know whether Pregnancy is present.
How early can it detect presence or absence of pregnancy?
Can it give false results?
Advantage
Urine Pregnancy Test can be done in secrecy.

DETECTING IN BLOOD
In normal pregnancy, hCG can be detected in serum as early as 7 days following
conception. The concentration of hCG continues to rise rapidly, frequently exceeding 100 mIU/ml by the first missed menstrual period and peaking in the
30-200,000 mIU/ml range by 10-12 weeks into pregnancy

.




How accurate is a urine pregnancy test?
PRACTICALLY
A]
Urine pregnancy test (UPT) kit is sensitive to detect 50 mIU/ml of hCG in urine.
(Some kits detect 25 mIU/ml).

One week before expected period hCG level in urine is between
5 to 50 mIU/ml.

Hence, practically urine pregnancy test can be relied upon not earlier than one week prior to expected date of next period. Commonly UPT is considered sensitive soon after missed period.

In case of doubt repeat the test 72 hours (3 days) later when the hCG further increases in urine. hCG levels double every 2 or 3 days.

VERY EARLY (IMMEDIATELY AFTER CONCEPTION)
B]
The UPT certainly cannot detect pregnancy the day after sexual intercourse, meaning immediately on conception. It takes time for hCG level to rise enough to be able to be detected by urine pregnancy test kit.

For detecting earlier, blood levels of hCG may be done in Pathology Laboratory, which is equipped with the test. It is however not done commonly as it is expensive and does not have the secrecy and ease of doing test at home.

For ensuring that pregnancy should not happen immediately after intercourse
'Emergency Contraception' is legally and medically approved.

Test Name	Lowest hCG detected
AimStick Pregnancy Test Strip	20 mIU
AccuHome Midstream Pregnancy Test	25 mIU
Accuclear Pregnancy Test	25 mIU
Answer Early Result Pregnancy Test	25 mIU
Clearblue Easy +/-	25 mIU
Clearblue Easy Digital (1 piece, blue cap)	25 mIU
Clear Choice w/ Cup	25 mIU
Confirm 1-Step Pregnancy Test	25 mIU
CVS Early Result Pregnancy Test	25 mIU
Dollar Store Brand (mini-strip, cassette, & midstream)	25 mIU
Early Detect	25 mIU
e.p.t. +/- Test	25 mIU
e.p.t. 1-Step Digital Test	25 mIU
e.p.t. Certainty Digital Test	25 mIU
Equate +/- (Wal-mart)	25 mIU
Equate Pregnancy Test (Wal-mart)	25 mIU
Fact Plus Midstream Pregnancy Test	25 mIU
First Response Early Result Pregnancy Test	25 mIU
One Step Be Sure Pregnancy Test	25 mIU
Right Aid Pregnancy Test	25 mIU
Target Brand Pregnancy Test	25 mIU
Walgreen Midstream Pregnancy Test	25 mIU
Walgreen Digital	25 mIU
Fact Plus Cassette	40 mIU
Clearblue Digital	50 mIU
CVS "Early Result" Cassette Pregnancy Test	50 mIU
Drug Emporium Brand Pregnancy Test	50 mIU
early Pregnancy test	50 mIU
Walgreens Cassette Pregnancy Test	50 mIU

Pregnancy Test Sensitivity Chart
Sensitivities checked with manufacturers in July 2007
All rights belong to
Source:
http://www.babyhopes.com/pregnancy-test-sensitivity.html

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erection-picture-animated

Click on the animated image to see tumescence and detumescence of penis.


The picture shows penis during erection. It also shows the process as erection subsides.
TO COPY IMAGE CLICK HERE
The image is licensed under Creative Commons License.
It may be freely used for educational purposes.
It is not to be used for sale or for commercial gain.
It is not to be used with alterations.
Credit for the image "Designed by Dr. Ashok Koparday" should go whereever the image is used.
Details:
Designed by Dr. Ashok Koparday.
Date of Creation
12/10/2007 7:02 PM
Image size
750 x 699
559 KB



Click upon the picture to see animation.
The original image is used from Gray's Text book of Anatomy edition 1928, which falls in public domain.

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how-to-win-man

Specially for her who is going to get married.
Useful for the married woman too.
Secrets to win a man.
What men want?
How to win them over to you?
Macho is not mucho!!!
Check this section.

Ask the Doctor. Now or Never.

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relationships-maintaining

We make friends even while commuting. It is easy enough.
Maintaining good relations lasting for life is not easy.

The following is specially contributed by
Senior Branch Manager, Saraswat Bank.

What a wonderful story!

-A possible Story ? ? ?
It could be yours ! ! !


You and your best friend have a fight..To Top of the Post
You decide not to talk to him ever.

He smiles at you.
You grind your teeth at him

He speaks nice about you.
You simply ignore him.
He tries to come and talk to you.
But you just push him aside.

He thinks you are a great friend.
You think he is a terrible friend.

He writes nice notes to you,
of the best times you shared together..To Top of the Post
You write about
all the bad times together.

Deep down you know he's sorry.
But all you have now is HATE.

And then you get a note.

It reads:
Dear [yourname],
I tried to tell you,
but you didn't let me speak,
I tried to tell good things,
but you were afraid to listen.

I tried to smile at you, to take away the hate.
But now it's time to tell, although a bit late.

I AM DYING.

I have a bad condition and it is getting worse.
I'm sorry but I won't be able to see you again.
I wrote this to you today in the hospital.To Top of the Post
My time is up. I should have told you sooner.

I'm sorry about our argument,
you are such a great friend.
I promise I shall watch over you,

Lots of love

You run to the hospital to ...........,
But only his mum is left.
Her hand clasped over her face.
And she was crying.
Down on her knees she prays,
for her son to come back.To Top of the Post

You are too late.
You wish you had come earlier,
and said sorry & goodbye.

All friends have their ups and downs,
and sometimes you need to say sorry.
Don't wait for the other person to do it first.
Because you never know what could happen.

If you really love your friends and would
watch down on them when you pass away,
please send this on and show people
that you really have a heart.

Share this even if it be with one person,

If you don't send this to anyone....
You could have lost yourself a friend,To Top of the Post

Coz if when you needed a friend,
There might not be just that one soul
who could have had read this letter.To Top of the Post

"Fate determines who comes into our lives."
"The heart determines who stays".

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body-building-medicine-2

A 22-year old body builder took two eight-week courses of
anabolic steroids. He became severely depressed after the
second course, and when the depression gradually receded, he
had prominent paranoid and religious delusions
(Pope and Katz, 1987).

In the previous chapter we saw important dangers and genuine uses of Methandienone.
There is more to it.


Pharmacodynamics

Anabolic steroids bind to specific receptors
present especially in reproductive tissue, muscle and.To Top of the Post
fat (Mooradian & Morley, 1987). The anabolic steroids
reduce nitrogen excretion from tissue breakdown in
androgen deficient men. They are also responsible for
normal male sexual differentiation. The ratio of
anabolic ("body-building") effects to androgenic
(virilizing) effects may differ among the members of
the class, but in practice all agents possess both
properties to some degree. There is no clear evidence.To Top of the Post
that anabolic steroids enhance overall athletic
performance (Elashoff et al, 1991).
Main adverse effects

The adverse effects of anabolic steroids include weight.To Top of the Post
gain, fluid retention, and abnormal liver function as
measured by biochemical tests. Administration to children can
cause premature closure of the epiphyses. Men can develop
impotence and azoospermia. Women are at risk of.To Top of the Post
virilization.
Endocrine and reproductive systems

Small doses of anabolic steroids are said to
increase libido, but larger doses lead to azoospermia
and impotence. Testicular atrophy is a common clinical.To Top of the Post
feature of long-term abuse of anabolic steroids, and
gynaecomastia can occur (Martikainen et al., 1986;
Schurmeyer et al., 1984; Spano & Ryan, 1984).
.To Top of the Post
Women develop signs of virilism, with increased facial
hair, male pattern baldness, acne, deepening of the
voice, irregular menses and clitoral enlargement
(Malarkey et al., 1991; Strauss et al., 1984).

Elimination by route of exposure.To Top of the Post

After administration of radiolabelled testosterone,
about 90% of the radioactivity appears in the urine, and 6%
in the faeces; there is some enterohepatic recirculation.To Top of the Post
(Wilson, 1992).

Distribution by route of exposure

The anabolic steroids are highly protein bound, and is
carried in plasma by a specific protein called sex-hormone.To Top of the Post
binding globulin.
The metabolism of absorbed drug is rapid, and the
elimination half-life from plasma is very short. The duration
of the biological effects is therefore determined almost.To Top of the Post
entirely by the rate of absorption from subcutaneous or
intramuscular depots, and on the de-esterification which
precedes it (Wilson, 1992).
Case reports from literature

A 38-year old man presented with acute urinary
retention, and was found to have carcinoma of the prostate..To Top of the Post
He had taken anabolic steroids for many years, and worked as
a "strong-man" (Roberts and Essenhigh, 1986).

A 22-year old male world-class weight lifter developed severe
chest pain awaking him from sleep, and was shown to have.To Top of the Post
myocardial infarction. For six weeks before, he had been
taking high doses of oral and injected anabolic steroids.
Total serum cholesterol was 596 mg/dL (HDL 14 mg/dL, LDL 513
mg/dL) (McNutt et al., 1988). Values of total cholesterol
concentration above 200 mg/dL are considered undesirable..To Top of the Post


A 19-year old American college footballer took intramuscular
testosterone and oral methandrostenolone over 4 months. He.To Top of the Post
became increasingly aggressive with his wife and child. After
he severely injured the child, he ceased using anabolic
steroids, and his violence and aggression resolved within 2.To Top of the Post
months (Schulte et al, 1993).

Specific preventive measures

Anabolic steroid abuse amongst athletes, weight.To Top of the Post
lifters, body builders and others is now apparently common at
all levels of these sports. Not all abusers are competitive
sportsmen.
There is therefore scope for a public health campaign, for
example, based on gymnasia, to emphasize the dangers of.To Top of the Post
anabolic steroid abuse and to support those who wish to stop
using the drugs.

REFERENCES.To Top of the Post

ABPI Data Sheet Compendium (1993) Datapharm Publications,
London.

Bowman S. (1990) Anabolic steroids and infarction. Br Med J;.To Top of the Post
300:

Cohen JC & Hickman R. (1987) Insulin Resistance and diminished
glucose tolerance in powerlifters ingesting anabolic steroids. J
Clin Endocrinol Metab 64: 960.
.To Top of the Post
Cohen JC, Noakes TD, & Spinnler Benade AJ. (1988)
Hypercholesterolemia in male power lifters using Anabolic
Androgenic Steroids. The Physician and Sports medicine 16:
49-56.
.To Top of the Post
Dalby JT. (1992) Brief anabolic steroid use and sustained
behavioral reaction. Am J Psychiatry 149: 271-272.

Dewhurst J. & Gordon RR (1984). Fertility following change of
sex: a follow-up. Lancet: ii: 1461-2.
.To Top of the Post
Elashoff JD, Jacknow AD, Shain SG, & Braunstein GD. (1991) Effects
of anabolic-androgenic steroids on muscular strength. Annals Inter
Med 115: 387-393..To Top of the Post

Falk H, Thomas LB, Popper H, Ishak KG. (1979). Hepatic
angiosacroma associated with androgenic-anabolic steroids. Lancet
2; 1120-1123.
.To Top of the Post
Ferner RE & Rawlins MD (1988) Anabolic steroids: the power and the
glory? Br Med J 1988; 297: 877-878.

Frankle MA, Eichberg R, & Zacharian SB. (1988) Anabolic Androgenic
steroids and stroke in an athlete: case report. Arch Phys Med
Rehabil 1988; 69: 632-633..To Top of the Post

Glazer G. (1991) Atherogenic effects of anabolic steroids on serum
lipid levels. Arch Intern Med 151: 1925-1933..To Top of the Post

Kennedy MC. (1992). Anabolic steroid abuse and toxicology. Aust NZ
J Med 22: 374-381.

Malarkey WB, Strauss RH, Leizman DJ, Liggett M, & Demers LM.
(1991). Endocrine effects in femal weight lifters who self-
administer testosterone and anabolic steroids. Am J Obstet.To Top of the Post
Gynecol 165: 1385-1390.

Martikainen H, Alen M, Rahkila P, & Vihko R. (1986) Testicular
responsiveness to human chorionic gonadotrophin during transient
hypogonadotrophic hypogondasim induced by androgenic/anabolic.To Top of the Post
steroids in power athletes. Biochem 25: 109-112.


McKillop G, Todd IC, Ballantyne D. (1986) Increased left
ventricular mass in a body builder using anabolic steroids. Brit J
Sports Med 20: 151-152.

McNutt RA, Ferenchick GS, Kirlin PC, & Hamlin NJ. (1988) Acute
myocardial infarction in a 22 year old world class weight lifter
using anabolic steroids. Am J Cardiol 62: 164..To Top of the Post

Mooradian JE, Morley JE, Korenman SG. (1987) Biological actions
of androgens. Endocrine Reviews 8:1-27.

Murad F, & Haynes RC. (1985). Androgens. in. Ed: Goodman Gilman
A, Goodman L S, Roll T W, Murad F. The Pharmacological Basis of
Therapeutics, 7th edition, Macmillan, New York: 1440-1458.To Top of the Post

Overly WL et al. (1984). Androgens and hepatocellular carcinoma in
an athlete. Ann Int Med 100: 158-159.

Pope GR, & Katz DL. (1988). Affective and psychotic symptoms
associated with anabolic steroid use. Am J Psychiatry 145:.To Top of the Post
487-490.

Reynolds Ed. (1992) Martindale-The Extra Pharmacopeia. The
Pharmaceutical Press. London.

Roberts JT, & Essenhigh DM. (1986) Adenocarcinoma of prostate in
40-year old body builder. Lancet 2: 742.

Ross RB, & Deutsch S I.(1990) Hooked on hormones. JAMA 263:.To Top of the Post
2048-2049.

Ryan A J. (1981) Anabolic steroids are fool's gold. Fed Proc 40:
2682-2688.

Schurmeyer T, Belkien L, Knuth UA, & Nieschlag E. (1984).To Top of the Post
Reversible azoospermia induced by the anabolic steroid
19-nortestosterone. Lancet i: 417-420.

Soe KL. Soe M. & Gluud C. (1992). Liver pathology associated
with the use of anabolic-androgenic steroids. Liver 12:
73-9.

Schulte HM, Hall MJ, & Boyer M. (1993). Domestic violence.To Top of the Post
associated with anabolic steroid abuse. Am J Psychiatr 150:
348.

Spano F, & Ryan W G. (1989) Tamoxifen for gynecomastia induced by
anabolic steroids? New Engl J Med 311: 861-862.

Strauss RH, Liggett MT, & Lanese RR. (1984) Anabolic steroid use
and perceived effects in 10 weight-trained women athletes JAMA.To Top of the Post
253: 2871-2873.


Su T-P, Pagliaro M, Schmidt PJ, Pickar D, Wolkowitz O, & Rubinow
DR. (1993) Neuropsychiatric effects of anabolic steroids in male
normal volunteers. JAMA 269: 2760-2764.

Wagner JC (1989). Abuse of drugs used to enhance athletic.To Top of the Post
performance. Am J Hosp Pharm 46: 2059-2067

Webb O L, Laskarzewski P M, & Glueck, CJ. (1984) Severe depression
of high-density lipo protein cholesterol levels in weight lifters
and body builders by self-administered exogenous testerone and.To Top of the Post
anabolic-andorgenic steroids. Metabolism 33: 971-975.

Wilson J D. (1992). Androgens. In: Goodman Gilman A., Rall T W,
Nies A S, & Taylor P. Goodman and Gilman's Pharmacological Basis
of Therapeutics. McGraw-Hill, Toronto. Pages 1413-1430.

AUTHOR(S), REVIEWER(S), DATE(S) (INCLUDING UPDATES), COMPLETE.To Top of the Post
ADDRESS(ES)

Author: Dr R. E. Ferner,
West Midlands Centre for Adverse Drug Reaction
Reporting,
City Hospital Dudley Road,.To Top of the Post
Birmingham B18 7QH
England.
Tel: +44-121-5074587
Fax: +44-121-5236125
Email: fernerre@bham.ac.uk

Date: 1994.To Top of the Post

Peer review: INTOX Meeting, Sao Paulo, Brazil, September 1994
(Drs P.Kulling, R.McKuowen, A.Borges, R.Higa,
R.Garnier, Hartigan-Go, E.Wickstrom)

Editor: Dr M.Ruse, March 1998
.To Top of the Post

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body-building-medicine-1

Medicines, called anabolic steroids contain METHANDIENONE.
You start lifting double the weights. Your weight increases by about ten kgs in the right places. You feel GOOD the whole day and feel FRESH on waking up. Your sexual drive DECREASES.

BODY BUILDING BRINGS TO MIND ONE NAME ARNOLD SWARZENEGGER.

Body building craze catches teenage boys. They often join a gymnasium. Word spreads around that there is a medicine that can increase biceps and give fullness and shape to body muscles. Like the macho cinema hero. Did you say Arnold Swarcheneggar?

a]
Main risks and target organs

There is no serious risk from acute poisoning, but.To Top of the Post
chronic use can cause harm. The main risks are those of
excessive androgens: menstrual irregularities and
virilization in women and impotence, premature cardiovascular
disease and prostatic hypertrophy in men. Both men and women
can suffer liver damage with oral anabolic steroids
containing a substituted 17-alpha-carbon. Psychiatric changes
can occur during use or after cessation of these
agents.

b]
Summary of clinical effects

Acute overdosage can produce nausea and gastrointestinal.To Top of the Post
upset. Chronic usage is thought to cause an increase in
muscle bulk, and can cause an exageration of male
characteristics and effects related to male hormones.
Anabolic steroids can influence sexual function. They can
also cause cardiovascular and hepatic damage. Acne and male-
pattern baldness occur in both sexes; irregular menses,
atrophy of the breasts, and clitoromegaly in women; and
testicular atrophy and prostatic hypertrophy in men..To Top of the Post

c]
Main adverse effects

The adverse effects of anabolic steroids include weight.To Top of the Post
gain, fluid retention, and abnormal liver function as
measured by biochemical tests. Administration to children can
cause premature closure of the epiphyses. Men can develop
impotence and azoospermia. Women are at risk of
virilization.

d]
USES.To Top of the Post
Indications

Anabolic agent; systemic
Anabolic steroid
Androstan derivative; anabolic steroid
Estren derivative; anabolic steroid
Other anabolic agent
Anabolic agent for systemic use; veterinary
Anabolic steroid; veterinary.To Top of the Post
Estren derivative; veterinary

e]
Description

The only legitimate therapeutic indications for
anabolic steroids are:

(a) replacement of male sex steroids in men who have.To Top of the Post
androgen deficiency, for example as a result of loss
of both testes

(b) the treatment of certain rare forms of aplastic
anaemia which are or may be responsive to anabolic
androgens.


(ABPI Data Sheet Compendium, 1993)

(c) the drugs have been used in certain countries to.To Top of the Post
counteract catabolic states, for example after major
trauma.
Source:
AUTHOR(S), REVIEWER(S), DATE(S) (INCLUDING UPDATES), COMPLETE
ADDRESS(ES)

Author: Dr R. E. Ferner,
West Midlands Centre for Adverse Drug Reaction.To Top of the Post
Reporting,
City Hospital Dudley Road,
Birmingham B18 7QH
England.
Tel: +44-121-5074587
Fax: +44-121-5236125
Email: fernerre@bham.ac.uk
.To Top of the Post
Date: 1994

Peer review: INTOX Meeting, Sao Paulo, Brazil, September 1994
(Drs P.Kulling, R.McKuowen, A.Borges, R.Higa,
R.Garnier, Hartigan-Go, E.Wickstrom)
Editor: Dr M.Ruse, March 1998
http://www.inchem.org/.To Top of the Post

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erectile-dysfunction-causes-medicines-3

Common medications associated with ED

o Antidepressants


o Antipsychotics


o Antihypertensives (for high blood pressure)


o Antiulcer drugs such as cimetidine (Tagamet).To Top of the Post


o Hormonal medication such as Zoladex, Lupron, finasteride (Proscar), or dutasteride (Avodart)


o Drugs that lower cholesterol


o Alcohol abuse

o Tobacco use for long duration

o Mind-altering agents such as marijuana and cocaine..To Top of the Post

These are the drugs or medications that are implicated in causing difficulty in Erectile Functions. .To Top of the Post

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erectile-dysfunction-causes-diseases-2

Common Causes of Impotence (Erectile Dysfuction) were covered in previous chapter.
DISEASE CONDITIONS
that cause Erectile Dysfunction [ED]:
Diabetes, High Blood Pressure (Hypertension) are the commonest causes that can lead to Erectile Dysfunctions. All the disease conditions that can cause ED are listed here.

* Systemic diseases associated with ED

o Diabetes.To Top of the Post


o Scleroderma


o Renal (kidney) failure


o Liver cirrhosis


o Hemochromatosis (too much iron in the blood)


o Cancer and cancer treatment.To Top of the Post


* Diseases of the nervous system associated with ED

o Epilepsy


o Stroke.To Top of the Post


o Multiple sclerosis


o Guillain-Barré syndrome


o Alzheimer disease


o Trauma.To Top of the Post


o Parkinson disease


* Respiratory disease associated with ED: Chronic obstructive pulmonary disease.To Top of the Post


* Endocrine conditions associated with ED

o Hyperthyroidism


o Hypothyroidism.To Top of the Post


o Hypogonadism


* Penile conditions associated with ED

o Peyronie disease.To Top of the Post


o Priapism (painful, abnormally prolonged erections)


* Mental conditions associated with ED

o Depression.To Top of the Post


o Widower syndrome


o Performance anxiety


* Nutritional states associated with ED

o Malnutrition.To Top of the Post


o Zinc deficiency


* Blood diseases associated with ED

o Sickle cell anemia.To Top of the Post


o Leukemias


* Surgical procedures associated with ED

o Procedures on the brain and spinal cord.To Top of the Post


o Retroperitoneal or pelvic lymph node dissection


o Aortoiliac or aortofemoral bypass.To Top of the Post


o Abdominal perineal resection


o Proctocolectomy


o Radical prostatectomy


o Transurethral resection of the prostate ([TUR] Prostrate Surgery).To Top of the Post


o Cryosurgery of the prostate.To Top of the Post


o Cystectomy

What are the medicines that can cause ED?

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intrapenile-injection-dangers

Injection Caverject©
Prolonged erection defined as erection lasting > 4 to ≤ 6 hours in duration occurred in 4% of 1861 patients treated up to 18 months in studies of CAVERJECT© Sterile Powder.
PRIAPISM is a much feared adverse effect of intra penile injection as it causes irreversible death of tissues of penis due to lack of fresh oxygen supply. Priapism is an emergency.
How to administer injections on penis has been covered in the previous chapter.
All other important side effects are given here.

Local Adverse Reactions:
The following local adverse reaction information was derived from controlled and uncontrolled studies, including an uncontrolled 18-month safety study.
TABLE 1 - Local Adverse Reactions Reported by ³ 1% of Patients Treated with Alprostadil for up to 18 Months*
Alprostadil
Event
N = 1861
Penile pain 37%
Prolonged erection 4%
Penile fibrosis** 3%
Injection site hematoma 3%
Penis disorder*** 3%
Injection site ecchymosis 2%
Penile rash 1%
Penile edema 1%
* Expected for penile pain (2%), no significant local adverse reactions were reported by 294 patients who received 1 to 3 injections of placebo.
** See PRECAUTIONS: General Precautions.
*** Included numbness, yeast infection, irritation, sensitivity, phimosis, pruritus, erythema, venous leak, penile skin tear, strange feeling of penis, discoloration of penile head, itch at tip of penis.

Penile Pain:
Penile pain after intracavernosal administration of Caverject was reported at least once by 37% of patients in clinical studies of up to 18 months in duration. In the majority of the cases, penile pain was rated mild or moderate in intensity. Three percent of patients discontinued treatment because of penile pain. The frequency of penile pain was 2% in 294 patients who received 1 to 3 injections of placebo.

Prolonged Erection/Priapism:
In clinical trials, prolonged erection was defined as an erection that lasted for 4 to 6 hours; priapism was defined as erection that lasted 6 hours or longer. The frequency of prolonged erection after intracavernosal administration of Caverject was 4%, while the frequency of priapism was 0.4%. In the majority of cases, spontaneous detumescence occurred. To minimize the chances of prolonged erection or priapism. Caverject should be titrated slowly to the lowest effective dose (see DOSAGE AND ADMINISTRATION).

The patient must be instructed to immediately report to his physician or, if unavailable, to seek immediate medical assistance for any erection that persists for longer than 6 hours. If priapism is not treated immediately, penile tissue damage and permanent loss of potency may result.

Hematoma/Ecchymosis: The frequency of hematoma and ecchymosis was 3% and 2%, respectively. In most cases, hematoma/ecchymosis was judged to be a complication of a faulty injection technique. Accordingly, proper instruction of the patient in self-injection is of importance to minimize the potential of hematoma/ecchymosis (see DOSAGE AND ADMINISTRATION).

The following local adverse reactions were reported by fewer than 1% of patients after injection of Caverject: balanitis, injection site hemorrhage, injection site-inflammation, injection site itching, injection site swelling, injection site edema, urethral bleeding, penile warmth, numbness, yeast infection, irritation, sensitivity, phimosis, pruritus, erythema, venous leak, painful erection, and abnormal ejaculation.
Generalised
Systemic Adverse Events: The following systemic adverse event information was derived from controlled and uncontrolled studies, including an uncontrolled 18-month safety study.

STRICTLY NOT TO BE USED IN FOLLOWING CONDITIONS:
1] Hypersensitivity to the [PGE1] drug,

2] in patients who have 1. sickle cell anemia or trait, 2. multiple myeloma, or leukemia, or in patients with anatomical deformation of the penis, such as angulation, cavernosal fibrosis, or 3. Peyronie's disease as they are likely to have priapism.

3]Patients with penile implants should not be treated with Alprostadil.

4]Alprostadil should not be used in women or children and is not for use in newborns.

5]Alprostadil should not be used in men for whom sexual activity is inadvisable or contraindicated.

TABLE 2 -
Systemic Adverse Events Reported by ³ 1% of Patients Treated with Caverject© for up to 18 Months*
Body System/Reaction ALPROSTADIL N=1861
Cardiovascular System
Hypertension 2%
Central Nervous System
Headache 2%
Dizziness 1%
Musculoskeletal System
Back pain 1%
Respiratory System
Upper respiratory infection 4%
Flu syndrome 2%
Sinusitis 2%
Nasal congestion 1%
Cough 1%
Urogenital System
Prostatic Disorder** 2%
Miscellaneous
Localized pain*** 2%
Trauma**** 2%
* No significant adverse events were more reported 294 patients who received 1 to 3 injections of placebo.
** prostatitis, pain, hypertrophy, enlargement
*** pain in various anatomical structures other than injection site
**** injuries, fractures, abrasions, lacerations, dislocations
The following systemic events, which were reported for

testicular pain, scrotal disorder, scrotal edema, hematuria, testicular disorder, impaired urination, urinary frequency, urinary urgency, pelvic pain, hypotension, vasodilation, peripheral vascular disorder, supraventricular extrasystoles, vasovagal reactions, hypesthesia, non-generalized weakness, diaphoresis, rash, non-application site pruritus, skin neoplasm, nausea, dry mouth, increased serum creatinine, leg cramps, and mydriasis.

Hemodynamic changes, manifested as decreases in blood pressure and increases in pulse rate, were observed during clinical studies, principally at doses above 20 micrograms and above 30 micrograms of alprostadil, respectively, and appeared to be dose-dependent. However, these changes were usually clinically unimportant; only three patients discontinued the treatment because of symptomatic hypotension.

DOES INJECTION FOR PENILE ERECTION AFFECT FERTILITY?
Caverject had no clinically important effect on serum or urine laboratory tests.
Carcinogenesis, Mutagenesis, and Impairment of Fertility: Long-term carcinogenicity studies have not been conducted. Rat reproductive studies indicate that alprostadil at doses of up to 0.2 milligram/kilogram/day does not adversely affect or alter rat spermatogenesis, providing a 200-fold margin of safety compared with the usual human doses.

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Erectile-Dysfunction-Cause

Vascular diseases account for nearly half of all cases of ED in men older than 50 years. Vascular disease includes

1. atherosclerosis (fatty deposits on the walls of arteries, also called hardening of the arteries),
2. a history of heart attacks,
3. peripheral vascular disease (problems with blood circulation), and
4. high blood pressure.
5. Prolonged tobacco use (smoking) is considered an important risk factor for ED because it is associated with poor circulation and reduced blood flow in the penis.

   The commonest cause of Erectile Dysfuction in young men (below 40 years) is unrealistic expectation.
   Dr. Ashok Koparday

   
   
   Almost any disease can affect erectile function by altering the

• nervous,
• vascular, or
• hormonal systems.

Various diseases may produce changes in the

• smooth muscle tissue of the penis or
• influence mood and behavior.
  
  Caverject ©
  
  MUSE ™
  Vivus Inc
  What are the causes in young boys who are about to get married or those who are just married?
  
  YOUNG ABOUT TO GET MARRIED
  All said and done, the most common cause of Erectile Dysfunction in young male of twenties and thirties is UNREALISTIC EXPECTATION.
  
  MYTHS
  Masturbation is bad is a myth.
  "My penis is small," is yet another myth.
  Such myths, which are nothing but false beliefs, can result in difficulty getting or maintaining erection. Those who are going to get married fear whether they will be able to do sex properly. "How shameful if I am not able to do sex (fail in inserting penis during sex)?"
  Fear of failure,
  performance anxiety are conditions that contribute to PERCEIVED erection problems in boys who are about to get married. Even a single instance of early discharge in the past during secret sexual affair makes a boy nervous and he fears failure in sex after marriage.
  "On the first wedding night (called as 'suhagrat') will I be able to do sex?"
  
  YOUNG JUST MARRIED
  Young just married guys commonly believe that they have Erectile Dysfunction when in fact due to vaginismus the opening of vaginal passage does not allow entry of penis resulting in unconsumated marriage.
  

  All said and done, more is said and less is done.

  
  
  

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