Can Sildenafil prevent heart attacks?
Uses of Viagra are two
1. Maintenance of Erection
2. Pulmonary Hypertension
The third use may be taking Sildenafil regularly to prevent hormonal damage to heart.
Can taking Sildenafil regularly be treatment for Heart Failure, Hypertrophy, Hypertension?
Dr. David Kass' Research Team will be starting clinical trial to see if Sildenafil can be effective in patients with heart failure.
In the words of Lead Researcher, Dr. David Kass, Professor of Medicine at John Hopkins:
"If you gave a drug like Viagra not just acutely, but chronically, you might be able to improve heart function and reduce the chronic stress response in patients with hypertrophy."
Viagra alters heart function when it is stimulated by hormonal stress
RESEARCH PREVIEW
Thursday, July 24, 2008
Viagra May Treat Heart Failure
The report appears in the Oct. 24 online edition of Circulation.
"Unlike what was previously thought, drugs like Viagra can in fact alter heart function," said lead researcher Dr. David Kass, a professor of medicine at Johns Hopkins. "It alters it particularly when the heart is stimulated by hormones."
1. Dr. David Kass, a professor of medicine at Johns Hopkins. Lead researcher
2. Rakesh C. Kukreja, a professor of medicine (opines; not a research team member)
Virginia Commonwealth University Medical Center.
Can be useful in the treatment of hypertension, hypertrophy, heart failure
By Steven Reinberg
HealthDay Reporter
http://www.medicinenet.com/script/main/art.asp?articlekey=55034
MONDAY, Oct. 24 (HealthDay News) -- Viagra ©, famous for improving men's sexual function, also appears to reduce the effects of hormonal stress on the heart by 50 percent, claims a report by researchers at Johns Hopkins University.
Viagra © (sildenafil) works by helping genital blood vessels expand to maintain an erection, but more recently, it has also been used as a treatment for pulmonary hypertension. However, the drug has been thought to have no direct effect on the heart.
"Unlike what was previously thought, drugs like Viagra can in fact alter heart function," said lead researcher Dr. David Kass, a professor of medicine at Johns Hopkins. "It alters it particularly when the heart is stimulated by hormones."
The report appears in the Oct. 24 online edition of Circulation.
Earlier research by Kass's team found that Viagra blocked the short-term effects of hormonal stress in the hearts of mice. They also found that, in mice, Viagra prevented and reversed the long-term cardiac effects of chronic high blood pressure.
In addition, Kass' group found that, in mice, Viagra reversed the negative effects on heart muscle weakened by heart failure and enlargement, a condition called hypertrophy.
"Viagra © puts a brake on the effect of dobutamine,"
David Kass noted that his group is starting a clinical trial to see if Viagra can be effective in patients with heart failure.
Rakesh C. Kukreja opines:
"This research may lead to the development of a new use of the drug in the treatment of diseases such as hypertension, hypertrophy and heart failure, where beta-adrenergic activity is enhanced following neurohormonal stimulation," said Rakesh C. Kukreja, a professor of medicine, physiology, biochemistry and emergency medicine and the Eric Lipman chair of cardiology at Virginia Commonwealth University Medical Center.
"These studies are complementary to the expanding new role of Viagra © and other relatively safe PDE-5A inhibitors as powerful cardioprotectants," he added.
SOURCES:
David Kass, M.D., professor, medicine, Johns Hopkins University School of Medicine, Baltimore;
Rakesh C. Kukreja, Ph.D, professor, medicine, physiology, biochemistry and emergency medicine,
Eric Lipman chair of cardiology, Virginia Commonwealth University Medical Center, Richmond;
Hrayr S. Karagueuzian, Ph.D., senior research scientist, Division of Cardiology, Cedars-Siani Medical Center, Los Angeles;
Oct. 24, 2005, Circulation online
Copyright © 2005 ScoutNews LLC. All rights reserved.
http://www.medicinenet.com/script/main/art.asp?articlekey=55034
Uses of Viagra are two
1. Maintenance of Erection
2. Pulmonary Hypertension
The third use may be taking Sildenafil regularly to prevent hormonal damage to heart.
Dr. David Kass' Research Team will be starting clinical trial to see if Sildenafil can be effective in patients with heart failure.
Research study suggests: Viagra© taken regularly not only protects heart (studies done in mice) from stress due to hormones and hypertension, but improves heart function.
In the words of Lead Researcher, Dr. David Kass, Professor of Medicine at John Hopkins:
"If you gave a drug like Viagra not just acutely, but chronically, you might be able to improve heart function and reduce the chronic stress response in patients with hypertrophy."
Viagra alters heart function when it is stimulated by hormonal stress
RESEARCH PREVIEW
Thursday, July 24, 2008
Viagra May Treat Heart Failure
The report appears in the Oct. 24 online edition of Circulation.
"Unlike what was previously thought, drugs like Viagra can in fact alter heart function," said lead researcher Dr. David Kass, a professor of medicine at Johns Hopkins. "It alters it particularly when the heart is stimulated by hormones."
1. Dr. David Kass, a professor of medicine at Johns Hopkins. Lead researcher
2. Rakesh C. Kukreja, a professor of medicine (opines; not a research team member)
Virginia Commonwealth University Medical Center.
Can be useful in the treatment of hypertension, hypertrophy, heart failure
By Steven Reinberg
HealthDay Reporter
http://www.medicinenet.com/script/main/art.asp?articlekey=55034
MONDAY, Oct. 24 (HealthDay News) -- Viagra ©, famous for improving men's sexual function, also appears to reduce the effects of hormonal stress on the heart by 50 percent, claims a report by researchers at Johns Hopkins University.
Viagra © (sildenafil) works by helping genital blood vessels expand to maintain an erection, but more recently, it has also been used as a treatment for pulmonary hypertension. However, the drug has been thought to have no direct effect on the heart.
"Unlike what was previously thought, drugs like Viagra can in fact alter heart function," said lead researcher Dr. David Kass, a professor of medicine at Johns Hopkins. "It alters it particularly when the heart is stimulated by hormones."
The report appears in the Oct. 24 online edition of Circulation.
Earlier research by Kass's team found that Viagra blocked the short-term effects of hormonal stress in the hearts of mice. They also found that, in mice, Viagra prevented and reversed the long-term cardiac effects of chronic high blood pressure.
In addition, Kass' group found that, in mice, Viagra reversed the negative effects on heart muscle weakened by heart failure and enlargement, a condition called hypertrophy.
"Viagra © puts a brake on the effect of dobutamine,"
David Kass noted that his group is starting a clinical trial to see if Viagra can be effective in patients with heart failure.
Rakesh C. Kukreja opines:
"This research may lead to the development of a new use of the drug in the treatment of diseases such as hypertension, hypertrophy and heart failure, where beta-adrenergic activity is enhanced following neurohormonal stimulation," said Rakesh C. Kukreja, a professor of medicine, physiology, biochemistry and emergency medicine and the Eric Lipman chair of cardiology at Virginia Commonwealth University Medical Center.
"These studies are complementary to the expanding new role of Viagra © and other relatively safe PDE-5A inhibitors as powerful cardioprotectants," he added.
SOURCES:
David Kass, M.D., professor, medicine, Johns Hopkins University School of Medicine, Baltimore;
Rakesh C. Kukreja, Ph.D, professor, medicine, physiology, biochemistry and emergency medicine,
Eric Lipman chair of cardiology, Virginia Commonwealth University Medical Center, Richmond;
Hrayr S. Karagueuzian, Ph.D., senior research scientist, Division of Cardiology, Cedars-Siani Medical Center, Los Angeles;
Oct. 24, 2005, Circulation online
Copyright © 2005 ScoutNews LLC. All rights reserved.
http://www.medicinenet.com/script/main/art.asp?articlekey=55034
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