USES
Who requires testosterone?
1. Women with advanced disseminated (last stage) breast cancer are treated with the most common testosterone-like drugs fluoxymesterone (Halotestin®) and methyltestosterone (Testred®).
2. In hormone-responsive tumors to reduce the tumor size.
3. Men and women with AIDS with wasting (weight loss without a clear cause) show remarkable improvement, increase in muscle mass, better immune response and feeling of well being when given testosterone treatment if testosterone levels are found to be below normal. [3]
Recent research has also indicated that at least half of all men living with AIDS suffer from hypogonadism, and that as many as 33 to 66% of women also have lower than normal testosterone values.
ABUSE
SPORTS ANTI DOPING TEST
Testosterone is banned from use in athletes by the US and the International Olympic Committees and other athletic organizations.
Testosterone and related drugs are in the 2005 Prohibited List of the World Anti-Doping Code.
Testosterone is usually excreted in the same amounts as epitestosterone. Consequently, the ratio of testosterone to epitestosterone in the urine (the T/E ratio) is used by anti-doping agencies as an indicator of testosterone misuse. According to the 2005 World Anti-Doping Code, if a 'laboratory has reported the presence of a T/E ratio of greater than four (4) to one (1) in the urine, further investigation is obligatory
SIDE EFFECTS
The most serious side effect of these drugs is hypercalcemia, a condition in which too much calcium circulates in the blood. This occurs because these drugs liberate calcium from bones. Calcium levels are monitored regularly, and the drug is discontinued if hypercalcemia occurs. Another serious (but less common) side effect is the development of tumors in the liver. Other side effects include deepening of the voice, development of facial hair and acne, fluid retention, and nausea.
—Tish Davidson, A.M.
REMEMBER
Side effects that you should report to your prescriber or health care professional as soon as possible:
• anxiety, depression
• breast tenderness or enlargement
• breathing problems
• black, tarry stools or light-colored stools
• dark yellow or brown urine
• erection lasting longer than 4 hours
• frequent erections
• frequent or difficult passing of urine
• nausea, vomiting
• skin rash and itching (hives)
• stomach pain
• unusual bleeding
• unusual swelling
• weight gain
• yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• acne
• change in taste or an unusual taste in your mouth
• gum infection or inflammation (gingivitis)
• headache
• redness, irritation, swelling and pain at the system application site
• sexual difficulties; changes in sexual desire
DRUG BRAND NAME
METHOD OF ADMINSITRATION
Brand names:
Andro-L.A.®, Androderm®, AndroGel®, Depandrate™, Depo-Testosterone®, First®-Testosterone, First®-Testosterone MC, Striant™, Testa Span™, Testerone™, Testim™, Testoderm®, Testone CYP 200, Tostrelle™, Tostrex™, Virilon® Injection
# sub-'Q' pellet
# Testosterone buccal system (below)
# Testosterone skin patches
# Testosterone skin gel - transdermal (cream, gel, or patch),
# Testosterone injection - Intramuscular injection
Testosterone must first be converted to 5α-dihydrotestosterone (DHT) before it is active.
— Saffron A. Whitehead
WHAT IS TESTOSTERONE BUCCAL SYSTEM
TESTOSTERONE (Striant™) is a naturally occurring male hormone. Testosterone is essential for maintaining normal male functions such as male sexual development, including the sex organs, increases in muscle mass, facial hair, and deep voice. Testosterone replaces natural hormone in men with low testosterone production, underdeveloped testes, and/or impotence.
Source:
www.thebody.com [4]
Jon Kaiser, M.D., author of Healing HIV
Current information on the availability and location of clinical trials can be found at the following web sites:
* National Cancer Institute. (800) 4-CANCER or .
* National Institutes of Health Clinical Trials. .
* Center Watch: A Clinical Trials Listing. .
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