The hallucinogenic? image is for sell at its website Url.
The mood of of people with depression and their care providers, that is spouses, the near ones who actually take care during illness, would be uplifted with two path breaking, promising treatments, perhaps cure, for depression.
Archives of General Psychiatry
'The study results have given us a completely novel way of treating depression and a new avenue of understanding depression,' said Bill Deakin, the head of the research team of the University of Manchester.
Date of Publication: Friday May 2, 2008.
The Three Pillars of Management of Depression today are:
Counseling
Medication
Surgical Management
Earlier ECT, Electro Convulsive Therapy, commonly known as SHOCK treatment was the sole means of treating severe depression, especially for those not responding to medicines or for those who could be jolted into quick recovery and later maintained on medication.
The American Association of Neurological Surgeons [1] in their
2008 Annual meeting. [2] raised hopes with surgical procedure of deep brain stimulation.
The British NeuroPhysicians came up with promising research of the effectiveness of special K or vitamin K [Ketamine] in the treatment/cure of Depression in their research published on Friday May 2, 2008.
Night club drug, a hallucinogen, called Special-K, is showing promise in the
treatment of resistant depression.
The latest findings give researchers a specific target to design new drugs [3] and offer hope for the many people who do not respond to Prozac or other standard medicines, Deakin added.
The record breaking drug, Prozac, and SSRI anti depressant, was initially introduced by U.S. drug maker Eli Lilly and Co in 1987 and belongs to a class of compounds called selective serotonin reuptake inhibitors (SSRIs). It is now off patent and widely available generically as fluoxetine.
"Many people don't respond to treatment," he said in a telephone interview. "This offers a potential way of treating them."
(Reporting by Michael Kahn; Editing by Jon Boyle)
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Treatment of Depression:
From 1987 to 2008 - 21 years
Prozac, the magic drug was approved. Even now it is one of the most popular medicine, which people pop in to get rid of their blues. Scientists have elevated mood and raised hope with their serious work.
Proof: DEEP BRAIN STIMULATION and KETAMINE
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We can go in to the discussion of the topics given above as per the requirement of the reader.
The study found that Ketamine affects the orbifrontal cortex, an area of the brain located above the eyes and believed to be responsible for feelings of guilt, dread, apprehension and certain other physical reactions. In depressed people, this area is overactive. However, the study, led by Bill Deakin, found that Ketamine restores it back to its normal state.
"The study results have given us a completely novel way of treating depression and a new avenue of understanding depression," Deakin, a neuroscientist at the University of Manchester, told the Associated Press.
Depression is a leading cause of suicide and affects about 121 million people worldwide, according to the World Health Organization
Brand name: Ketalar® Ketamine injection What is ketamine injection? KETAMINE (Ketalar®) reduces anxiety and tension, and promotes relaxation and sleep before surgery or other procedures. Ketamine is used before short diagnostic tests and surgical procedures and may supplement other types of general anethesia. Generic ketamine injections are available. |
In their study, Deakin and his team gave intravenous ketamine to 33 healthy male volunteers and took minute-by-minute brain scans to see what was happening as the drug took effect.
Images from the scans showed that the drug -- also used as a battlefield anesthetic -- worked quickly, Deakin said.
In the study, 33 healthy male volunteers were given ketamine. Deakin and his team then took minute-by-minute brain scans to see what was happening as the drug took effect.
The images revealed the drug worked quickly.
The results were surprising because the researchers had expected that ketamine, sometimes used as a battlefield anesthetic, would instead affect the part of the brain that controls psychosis, according to Deakin.
"There was some activity there but more striking was the switching off of the depression centre," he said.
Although prior research had found that ketamine improved symptoms of depression after 24 hours, scientists were not clear precisely how.
The new findings now provide researchers a specific target in designing new drugs and offer hope for the many patients who do not respond to Prozac, which can take a month to kick in, or other standard medicines, Deakin added.
Prozac, initially introduced by U.S. drugmaker Eli Lilly in 1987, belongs to a class of compounds called selective serotonin reuptake inhibitors (SSRIs). It is now off patent and commonly available in generic form as fluoxetine.
"Many people don't respond to treatment," Deakin said in during a telephone interview with the Associated Press.
"This offers a potential way of treating them."
SIDE EFFECTS OF COMMONLY USED ANTIDEPRESSANTS
1.Duloxetine<
2. Paroxetine
3. Venlafaxine
4. Alprazolam
The study was published in the Archives of General Psychiatry.
Ketamine has a well-documented neuroprotective effect against ischemic brain-injury and glutamate induced brain injury. One hypothesis of its working mechanism in case of chronic pain management and depression is that it works as an anti-dote to an overactivity and in glutamergic brain circuits.
TEAM OF RESEARCH SCIENTISTS
J. F. William Deakin, PhD, FRCPsych, FmedSci; Jane Lees, BSc, MSc; Shane McKie, MEng, MSc, PhD; Jaime E. C. Hallak, MD, PhD; Steve R. Williams, BA, MA, DPhil; Serdar M. Dursun, MD, PhD, FRCPC
Arch Gen Psychiatry. 2008;65(2):154-164.
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| [1] | [2] | [3] | [4] | [5] |
NEWS REFERENCES
THE TIMES OF INDIA
Further Reading
rte.ie
a1b2c3.com
rxlist.com
drugdigest.org
drugs.com
micro.magnet.fsu.edu
virtualpaincenter.com
answers.com
wikipedia.org
Dr. Ashok Koparday
MBBS, FC SEPI
Medical Director
Samadhan India
Center for Therapy, Education, Research in
Sex, Marriage, Relationships
Ex. Teaching Faculty
Seth G. S. Medical College and K. E. M. Hospital and
Grant Medical College and Sir J. J. Group of Hospitals
University of Mumbai, India
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